' 
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Curcumin protects neurons in sleep apnea
Curcumin triggers the Wnt/β-catenin pathway and shields neurons from injury caused by intermittent hypoxia.
High relevance to sleep apnea treatment
We investigated how Curcumin, a compound found in turmeric, may help reduce neuronal damage linked to obstructive sleep apnea (OSA). Using a cell model that simulates intermittent hypoxia, we assessed various factors such as cell health, toxicity, apoptosis (cell death), and the activity of a specific signaling pathway known as Wnt/β-catenin.
Our findings revealed that intermittent hypoxia increases cell death and harmful toxicity while suppressing cell growth and the Wnt/β-catenin pathway. However, when we introduced Curcumin, we noted significant improvements. Cell viability rose, apoptosis rates fell, and cell proliferation was promoted. Additionally, Curcumin helped activate the Wnt/β-catenin pathway, which is crucial for cell survival and function.
To further test our results, we created an animal model of intermittent hypoxia. In this model, Curcumin treatment managed to reduce damage to the hippocampus and restore Wnt/β-catenin pathway activity, validating our cell-based findings. Overall, these promising results suggest that Curcumin might be an innovative approach to battling neurological impairments caused by sleep apnea.
Our findings revealed that intermittent hypoxia increases cell death and harmful toxicity while suppressing cell growth and the Wnt/β-catenin pathway. However, when we introduced Curcumin, we noted significant improvements. Cell viability rose, apoptosis rates fell, and cell proliferation was promoted. Additionally, Curcumin helped activate the Wnt/β-catenin pathway, which is crucial for cell survival and function.
To further test our results, we created an animal model of intermittent hypoxia. In this model, Curcumin treatment managed to reduce damage to the hippocampus and restore Wnt/β-catenin pathway activity, validating our cell-based findings. Overall, these promising results suggest that Curcumin might be an innovative approach to battling neurological impairments caused by sleep apnea.
Read More
9
Curcumin may improve sleep apnea
Curcumin activates the Wnt/β-catenin signaling pathway to alleviate hippocampal neurogenesis abnormalities caused by intermittent hypoxia: A study based on network pharmacology and experimental verification.
Moderate relevance to sleep apnea
This study delves into the effect of curcumin, a natural compound found in turmeric, on cognitive function and neurogenesis issues linked to obstructive sleep apnea (OSA), particularly when faced with intermittent hypoxia (IH). We analyzed potential targets for curcumin as a treatment using network pharmacology, alongside conducting experiments on mice and neural stem cells to observe the treatment's outcomes.
Through the Morris water maze test, we noticed that curcumin significantly improved cognitive dysfunction caused by IH. Our histological assessments revealed that curcumin helped protect against hippocampal damage resulting from sleep apnea. Notably, we found that curcumin appears to enhance neurogenesis by initiating the Wnt/β-catenin signaling pathway, which is crucial for brain cell development.
Additionally, in laboratory tests, curcumin demonstrated protective effects against IH-induced injuries in neural stem cells, suggesting a positive impact on brain health. Overall, these findings support the potential of curcumin as a promising treatment avenue for neurological challenges associated with obstructive sleep apnea.
Through the Morris water maze test, we noticed that curcumin significantly improved cognitive dysfunction caused by IH. Our histological assessments revealed that curcumin helped protect against hippocampal damage resulting from sleep apnea. Notably, we found that curcumin appears to enhance neurogenesis by initiating the Wnt/β-catenin signaling pathway, which is crucial for brain cell development.
Additionally, in laboratory tests, curcumin demonstrated protective effects against IH-induced injuries in neural stem cells, suggesting a positive impact on brain health. Overall, these findings support the potential of curcumin as a promising treatment avenue for neurological challenges associated with obstructive sleep apnea.
Read More
8
Curcumin alleviates brain injury
Curcumin attenuates chronic intermittent hypoxia-induced brain injuries by inhibiting AQP4 and p38 MAPK pathway.
Curcumin's effects on brain damage
We explored the promising effects of curcumin, a compound found in turmeric, on brain injuries caused by chronic intermittent hypoxia (CIH), a condition often linked to obstructive sleep apnea (OSA). In our study, male balb/c mice were subjected to a specific pattern of CIH for a total of ten weeks. During this time, they received daily treatments of curcumin at varying doses or a control solution, enabling us to assess its potential benefits on brain health.
Our findings revealed that exposure to CIH led to significant brain edema, neuronal cell death, and astrogliosis in areas of the brain such as the cerebral cortex and cerebellum. Notably, we also observed increased expression of AQP4, a water channel protein, and activation of the p38 MAPK pathway after CIH exposure. Remarkably, curcumin treatment appeared to alleviate these harmful effects in a dose-dependent manner, suggesting it offers neuroprotection against the injuries induced by CIH.
Overall, it seems that curcumin may help reduce brain edema and neuronal damage associated with CIH, showcasing its potential as a therapeutic option for conditions like sleep apnea. However, while our study highlights curcumin's benefits, further research is needed to fully understand its role in addressing sleep apnea directly.
Our findings revealed that exposure to CIH led to significant brain edema, neuronal cell death, and astrogliosis in areas of the brain such as the cerebral cortex and cerebellum. Notably, we also observed increased expression of AQP4, a water channel protein, and activation of the p38 MAPK pathway after CIH exposure. Remarkably, curcumin treatment appeared to alleviate these harmful effects in a dose-dependent manner, suggesting it offers neuroprotection against the injuries induced by CIH.
Overall, it seems that curcumin may help reduce brain edema and neuronal damage associated with CIH, showcasing its potential as a therapeutic option for conditions like sleep apnea. However, while our study highlights curcumin's benefits, further research is needed to fully understand its role in addressing sleep apnea directly.
Read More
Most Useful Reviews
9.5
Joint pain relief
I took it to my father, who has arthritis. I read that curcumin is a good anti-inflammatory for such a diagnosis. After a few days of taking it, the pain diminished, and I began to sleep normally. I ordered it alongside other vitamins, so we shall see what happens next, but at present, we notice an improvement, as his joints hurt less.
Read More
6.8
Improved sleep duration
Turmeric seems to help me sleep a little longer. I suffer from severe chronic insomnia, and sometimes it allows me to get a bit more rest, which is invaluable for my sleep apnea.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
9
Curcumin protects neurons in sleep apnea
Curcumin triggers the Wnt/β-catenin pathway and shields neurons from injury caused by intermittent hypoxia.
High relevance to sleep apnea treatment
We investigated how Curcumin, a compound found in turmeric, may help reduce neuronal damage linked to obstructive sleep apnea (OSA). Using a cell model that simulates intermittent hypoxia, we assessed various factors such as cell health, toxicity, apoptosis (cell death), and the activity of a specific signaling pathway known as Wnt/β-catenin.
Our findings revealed that intermittent hypoxia increases cell death and harmful toxicity while suppressing cell growth and the Wnt/β-catenin pathway. However, when we introduced Curcumin, we noted significant improvements. Cell viability rose, apoptosis rates fell, and cell proliferation was promoted. Additionally, Curcumin helped activate the Wnt/β-catenin pathway, which is crucial for cell survival and function.
To further test our results, we created an animal model of intermittent hypoxia. In this model, Curcumin treatment managed to reduce damage to the hippocampus and restore Wnt/β-catenin pathway activity, validating our cell-based findings. Overall, these promising results suggest that Curcumin might be an innovative approach to battling neurological impairments caused by sleep apnea.
Our findings revealed that intermittent hypoxia increases cell death and harmful toxicity while suppressing cell growth and the Wnt/β-catenin pathway. However, when we introduced Curcumin, we noted significant improvements. Cell viability rose, apoptosis rates fell, and cell proliferation was promoted. Additionally, Curcumin helped activate the Wnt/β-catenin pathway, which is crucial for cell survival and function.
To further test our results, we created an animal model of intermittent hypoxia. In this model, Curcumin treatment managed to reduce damage to the hippocampus and restore Wnt/β-catenin pathway activity, validating our cell-based findings. Overall, these promising results suggest that Curcumin might be an innovative approach to battling neurological impairments caused by sleep apnea.
Read More
9
Curcumin may improve sleep apnea
Curcumin activates the Wnt/β-catenin signaling pathway to alleviate hippocampal neurogenesis abnormalities caused by intermittent hypoxia: A study based on network pharmacology and experimental verification.
Moderate relevance to sleep apnea
This study delves into the effect of curcumin, a natural compound found in turmeric, on cognitive function and neurogenesis issues linked to obstructive sleep apnea (OSA), particularly when faced with intermittent hypoxia (IH). We analyzed potential targets for curcumin as a treatment using network pharmacology, alongside conducting experiments on mice and neural stem cells to observe the treatment's outcomes.
Through the Morris water maze test, we noticed that curcumin significantly improved cognitive dysfunction caused by IH. Our histological assessments revealed that curcumin helped protect against hippocampal damage resulting from sleep apnea. Notably, we found that curcumin appears to enhance neurogenesis by initiating the Wnt/β-catenin signaling pathway, which is crucial for brain cell development.
Additionally, in laboratory tests, curcumin demonstrated protective effects against IH-induced injuries in neural stem cells, suggesting a positive impact on brain health. Overall, these findings support the potential of curcumin as a promising treatment avenue for neurological challenges associated with obstructive sleep apnea.
Through the Morris water maze test, we noticed that curcumin significantly improved cognitive dysfunction caused by IH. Our histological assessments revealed that curcumin helped protect against hippocampal damage resulting from sleep apnea. Notably, we found that curcumin appears to enhance neurogenesis by initiating the Wnt/β-catenin signaling pathway, which is crucial for brain cell development.
Additionally, in laboratory tests, curcumin demonstrated protective effects against IH-induced injuries in neural stem cells, suggesting a positive impact on brain health. Overall, these findings support the potential of curcumin as a promising treatment avenue for neurological challenges associated with obstructive sleep apnea.
Read More
8
Curcumin alleviates brain injury
Curcumin attenuates chronic intermittent hypoxia-induced brain injuries by inhibiting AQP4 and p38 MAPK pathway.
Curcumin's effects on brain damage
We explored the promising effects of curcumin, a compound found in turmeric, on brain injuries caused by chronic intermittent hypoxia (CIH), a condition often linked to obstructive sleep apnea (OSA). In our study, male balb/c mice were subjected to a specific pattern of CIH for a total of ten weeks. During this time, they received daily treatments of curcumin at varying doses or a control solution, enabling us to assess its potential benefits on brain health.
Our findings revealed that exposure to CIH led to significant brain edema, neuronal cell death, and astrogliosis in areas of the brain such as the cerebral cortex and cerebellum. Notably, we also observed increased expression of AQP4, a water channel protein, and activation of the p38 MAPK pathway after CIH exposure. Remarkably, curcumin treatment appeared to alleviate these harmful effects in a dose-dependent manner, suggesting it offers neuroprotection against the injuries induced by CIH.
Overall, it seems that curcumin may help reduce brain edema and neuronal damage associated with CIH, showcasing its potential as a therapeutic option for conditions like sleep apnea. However, while our study highlights curcumin's benefits, further research is needed to fully understand its role in addressing sleep apnea directly.
Our findings revealed that exposure to CIH led to significant brain edema, neuronal cell death, and astrogliosis in areas of the brain such as the cerebral cortex and cerebellum. Notably, we also observed increased expression of AQP4, a water channel protein, and activation of the p38 MAPK pathway after CIH exposure. Remarkably, curcumin treatment appeared to alleviate these harmful effects in a dose-dependent manner, suggesting it offers neuroprotection against the injuries induced by CIH.
Overall, it seems that curcumin may help reduce brain edema and neuronal damage associated with CIH, showcasing its potential as a therapeutic option for conditions like sleep apnea. However, while our study highlights curcumin's benefits, further research is needed to fully understand its role in addressing sleep apnea directly.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
9.5
Joint pain relief
I took it to my father, who has arthritis. I read that curcumin is a good anti-inflammatory for such a diagnosis. After a few days of taking it, the pain diminished, and I began to sleep normally. I ordered it alongside other vitamins, so we shall see what happens next, but at present, we notice an improvement, as his joints hurt less.
Read More
6.8
Improved sleep duration
Turmeric seems to help me sleep a little longer. I suffer from severe chronic insomnia, and sometimes it allows me to get a bit more rest, which is invaluable for my sleep apnea.
